A new generation of biocompatible nanoparticles made of resorbable poly(ester amide)s

Authors

  • T. Kantaria Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • T. Kantaria Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • G. Titvinidze Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • S. Kobauri Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • M. Ksovreli Cellular Immunology Laboratory, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • T. Kachlishvili Cellular Immunology Laboratory, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • N. Kulikova Cellular Immunology Laboratory, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • D. Tugushi Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia
  • R. Katsarava Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia 240, David Aghmashenebeli Ave., Tbilisi, 0159, Georgia

Keywords:

Biodegradable polymers; Nanoprecipitation; Nanoparticles; Biodegradable surfactant; PEGylation; in vitro cell compatibility

Abstract

A new generation of resorbable nanoparticles (NPs) were prepared on the basis of amino acid based biodegradable (AABB) poly(ester amide)s (PEAs) for drug delivery application. The NPs were fabricated by cost-effective polymer deposition/solvent displacement (nanoprecipitation) method on the basis of three different AABB PEAs recently developed by our group: (i) PEA composed of amino acid leucine as a basic component, (ii) cationic PEA composed of amino acid arginine for imparting positive charge, and (iii) functional PEA composed of amino acid leucine and lateral poly(ethylene glycol) groups acting as surfactant as well as PEGylating agent. The mean particle diameter (MPD), polydispersity index (PDI) and zeta-potential (ZP) were determined by Dynamic Light Scattering (DLS). Moreover, the stability (resuspendability) of the NPs over the time at low temperature was investigated. The NPs were studied for in vitro cell compatibility using four different stable cell lines: A549 (human), U937 (human), RAW264.7 (murine), Hepa 1-6 (murine). Prepared nanoparticles exhibit high stability and cell compatibility and have potential for the application as drug delivery devices.

Additional Files

Published

05-02-2020

How to Cite

Kantaria, T., Kantaria, T., Titvinidze, G., Kobauri, S., Ksovreli, M., Kachlishvili, T., Kulikova, N., Tugushi, D., & Katsarava, R. (2020). A new generation of biocompatible nanoparticles made of resorbable poly(ester amide)s. The Journal of Nature Studies - Annals of Agrarian Science, 17(1). Retrieved from https://journals.org.ge/index.php/aans/article/view/298

Issue

Vol. 17 No. 1 (2019): Annals of Agrarian Science

Section

Articles

Most read articles by the same author(s)