Effect of microscopic fungi lysates on Ehrlich carcinoma growth

Abstract

The article presents the influence of biologically active substances NL-51, T1 and K1 (supernatants, isolated from microscopic fungi collected from different regions of Georgia) on Ehrlich’s carcinoma growth in mice. Investigations have shown that T1 and K1 samples reveal inhibitory activity on proteolytic enzymes that supposedly explains their anticancer effects (increased lifespan of treated carcinoma-bearing mice compared to control mice). The opposite effect was observed in case of NL-51 treated mice. NL-51 did not show inhibitory properties on proteolytic enzymes and the life span of treated animals was not prolonged compared to the control group animals.